Frequently Asked Questions
Biological pacemaker and implantation catheter
Inventors: Syde A. Taheri, Howard J. Leonhardt
US Patent 6690970 B1
A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions.
What is the BioPace therapy?
What studies have been done?
In vitro, we have demonstrated that functional coupling can occur between cardiocytes and other cell types across multi-perforated membranes patented as PerFLexMEA. These studies demonstrate that pacemaker cells held within a scaffold can communicate with cardiocytes outside the scaffold to stimulate and pace the heart.
We have also characterized (in vitro) the pharmacological response of cardiocytes. In a study published by [INSERT AUTHOR ET AL] in [INSERT JOURNAL TITLE], blood macrophages were successfully transformed into cardiocytes, which responded differentially to antiarrhythmic drugs.
What does bioelectric stimulation attempt to do?
First, bioelectric stimulation will be used to train engineered autorhythmic cells within the scaffold to beat at different rates, depending on the patient. Younger patients can require basal beating frequencies close to 250 bpm while older patients may require a basal frequency of 60 – 70 bpm.
Second, bioelectric stimulation can be used after the implantation of the BioPace scaffold to:
1. Home stem cells to treatment site via expressions of SDF1 and PDGF.
2. Release growth factors such as VEGF, PDGF, SDF1, HGF, EGF, CXCL5 and eNOS to improve blood supply to treated region.
3. Releases factors known to promote regeneration such as Klotho and IGF1.
4. Promotes proliferation of stem cells on demand.
5. Promotes controlled differentiation of cells.
6. Trains newly formed pacing cells to pace in synchrony with heart.